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ArtistX is a live DVD which turns a computer into a full multimedia production studio. It is based on Debian GNU/Linux and contains nearly all the available free audio, 2D and 3D graphics, and video software for the GNU/Linux computing platform. It doesn't need to be installed, and boots directly into a running system without touching hard drives. The files produced with ArtistX can be easily stored on USB devices or CD/DVD medium while it is running.

Dynebolic GNU/Linux is a live bootable distribution, an operating system which works directly from the CD without the need to install or change anything on the hard disk. It is user-friendly, recognizes your hardware devices (sound, video, firewire, and USB), and offers a vast range of software for multimedia production, streaming, 3D modeling, photo, peer-to-peer filesharing, Web browsing and publishing, word processing, email, encryption, and networking. It also includes games and a world navigator. It does automatic clustering, joining the CPU power between any other dyne:bolic on the local network, and works on modded XBOX consoles as well.

GeeXboX is no more than a standalone media player. Its main purpose is to play DivX movies. So, GeeXboX is a full operating system, running under Linux and based on the excellent MPlayer. No need of hard drive, you just have to put the GeeXboX bootable CD into the CD-Drive of any pentium-class computer to boot it.

Grafpup Linux is a desktop operating system with a focus on providing a complete and stable workflow for digital imaging professionals and graphic artists in a very compact package. It runs quite well as a live cd but with persistent storage for your data and a nice package management system for addon software. Packages can even be installed when running the OS from the live cd and will remain there when you reboot. It can also install quite easily to a usb thumbdrive or your hard disk and runs equally well. Based on Puppy Linux.

Musix is a 100% Free Operating system intended for musicians and all kind of users. It contains an enormous collection of free programs: Rosegarden, Ardour, Jamin, Hydrogen, cheesetracker, jackd, Rezound, Beast, Lilypond, qjackctl, Puredata, Tarini

Ubuntu Studio is a variant of Ubuntu aimed at the GNU/Linux audio, video and graphic enthusiast as well as professional. The distribution provides a collection of open-source applications available for multimedia creation.